Uridine is a nucleotide base which can be found in high levels in beer. It's used for increasing synthesis of cellular membranes and for cognitive enhancement. Synergistic with fish oil, it also stacks well with choline for improved cognition.
Naturally occuring in certain foods. As mentioned, it's found in beer, but also in breast milk, some infant formulas, organ meat, cruciferous vegetables, yeast, mushrooms, parsley, chestnuts, broccoli, oats, Chinese cabbage, spinach, sugar cane, barley, cauliflower, and tomatoes contain uridine.
The chemical compound is found primarily in the nucleus of a cell. It's one of 5 nucleosides that form nucleic acid. Nucleic acid is a critical part of Ribonucleic acid (RNA), which is fundamental to the cell structure of the nucleus.
Uridine is biosynthesized by the liver as Uridine monophosphate. Uridine monophosphate is secreted into the bloodstream. When in the bloodstream, it helps cell rejuvenation. It can also show in the bloodstream as uridine triphosphate or uridine 5 monophosphate. One of its primary functions is enhancing cognition and improving alertness.
You can get it from your diet, but supplementing with uridine may help with your fitness and cognitive wellness.
How it works
It promotes new neuronal interconnections within the brain to supports cognition. It's a mental stimulant that enhances brain activity and improves the ability to store and consolidate memories. It also affects mood. When someone is experiencing uridine deficits they may experience both short and long term memory loss and anxiety.
Acting as a neuroprotective, strengthening brain cells. It may help to prevent the onset of age related cognitive issues, such as dementia or Alzheimer’s.
It improves the dopamine levels within the brain. Which helps to improve motivation, focus and encourages the reward feedback cycle.
It may be effective at improving mood, memory and other cognitive tasks. It's also possible that it can reverse certain brain traumas. Some clinical trials show improvements in some Alzheimer’s patients with mild symptoms, after supplementing with uridine. It may protect the brain from memory loss, especially memory loss due to anxiety or stress.
It reduces inflammation and could promote muscle growth. So, it's occasionally used by athletes to help recovery and muscle growth. In a study involving carpal tunnel syndrome patients, uridine was combined with folic acid and vitamin B12. Patients experienced relief in pain. Studies on mice also showed anti-inflammatory effects that may relieve symptoms of fibrosis.
The benefits of uridine are not confined to just the brain. It's been shown that uridine triphosphate may reduce the risk of having a heart attack and improve overall heart health. It may also significantly reverse osteoporosis.
Stacks for improved cognition
- Uridine: Uridine Monophopshate taken once a day at 150-200mg or Triacetyluridine taken at 25-50mg/day.
- DHA (Fish Oil): 1-2 grams/day of a high quality, DHA-rich fish oil, with for a daily total of at least 700mg of DHA.
- Choline (Alpha-GPC): Start with 300mg of Alpha-GPC and very slowly increase dosage if needed (max 450mg day).
- B-Complex (Optional): B-Complex supplementation can be added as uridine slows the body's supply of Vitamin B9 (folate) and Vitamin B12 (cobalamin).
Some studies have shown it can cause diarrhea, fever, palpitations or gastrointestinal discomfort. The effects generally come on within 30 minutes of ingestion and pass within an hour.
Uridine doesn't have a set dosage. Most people tend to use between 500mg and 1,000mg once or twice a day. It's advised you take it with a meal. As with any supplement, always consult with your doctor before you start to take it.
Where to buy
We recommend Doublewood Supplements.
Have you used this nootropic before? Did you experience any benefits?