Sulbutiamine – A Memory & Mood Booster

Sulbutiamine is a man-made chemical similar to Vitamin B1, to treat chronic fatigue. It also enhances memory and focus, and it may even improve motivation and mood.

What Is Sulbutiamine?

Sulbutiamine is a laboratory-created molecule created by binding two thiamine molecules together by a sulfur group. The resulting structure makes sulbutiamine more bioavailable and improves its ability to cross the blood-brain barrier.

The molecule was discovered by Japanese researchers who were searching for a treatment for beriberi. A nervous disorder which is the result of a thiamine deficiency.


More recent studies have shown that sulbutiamine has the potential to treat various types of chronic fatigue.

It has been shown to boost cognition and memory by promoting increased production of the neurotransmitter acetylcholine. It also increases levels of dopamine and glutamate which improve mood and energy.

Improved Memory and Cognition

A study of early-stage Alzheimer’s patients showed those who received sulbutiamine in addition to an Alzheimer’s treatment drug (donepezil) for six months improved in attention, episodic memory, and daily life activities.

Improved Energy and Alertness

Sulbutiamine has been used successfully to treat a variety of types of fatigue, due to its ability to upregulate the production of glutamate, the most crucial excitatory neurotransmitter.

Reduce Anxiety and Improve Mood

Many users report a positive effect on motivation, mood, reducing anxiety and improving general well-being.

It has also been shown to upregulate cortical transmissions of dopamine. Dopamine is the neurotransmitter associated with reward, pleasure and other emotional responses. Therefore, increasing dopamine levels could be expected to enhance motivation and mood.

One study of patients with major depressive disorder showed it reduced fear and anxiety and helped them function better in all aspects of their lives.

How It Works

Readily crosses the blood-brain barrier, it encourages the formation of thiamine triphosphate, which regulates the synaptic transmission of neurotransmitters, including glutamate, acetylcholine and dopamine.

It's a substance that promotes the production of choline. It has been shown to inhibit the enzyme acetylcholinesterase. This breaks down acetylcholine prolonging its action.

It starts to work within one day, and the duration of action is about one day, with a half-life of around 5 hours.


Studies and clinical trials on humans have used a daily dosage of up to 600 mg.

The safety and effectiveness of long-term use of sulbutiamine are unknown. There are no official reports of side effects, but some have been anecdotally reported.

Many users recommend taking sulbutiamine occasionally or in cycles up to 4 weeks, rather than continuously, to avoid tolerance.

Side Effects

It's well-tolerated and considered safe when taken in moderate amounts and over a limited period.

The only reported side effects have been sleeplessness, a mild and transient headache and a stomach upset. No toxicity has been reported.


Here are some stack ideas;

Aniracetam + Choline + Sulbutiamine Stack

Sulbutiamine stacks well with the racetams. Stacking sulbutiamine with aniracetam is useful as aniracetam has a similar effect on mood and cognition.

1–2x per day

Huperzine A + Choline + Sulbutiamine Stack

For increased focus and attention;

1–2x per day

Where to Buy

We recommend purchasing from Absorb Your Health, which is a reputable site.

Have you used Sulbutiamine? Did you experience positive results?

Leave a Comment

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.