Phosphatidylserine – For A Sharp Mind

Phosphatidylserine is a fatty substance also called a phospholipid. It covers and protects the cells in your brain and carries messages between them. It helps to maintain cellular health, improves mood, problem-solving, reasoning, focus, memory, and learning ability, reduces the effects of stress and has been proven to slow or even reverse age-related mental decline.


Phosphatidylserine (PS) is an extremely important compound that naturally occurs in all species. The body can make Phosphatidylserine, but it gets most of what it needs from foods (meat, soy lecithin, and some fatty fish).

Studies have shown that the levels of PS decline with age. So supplementation with PS would have many therapeutic and nootropic benefits.

Originally PS supplements were made from cow brains. Typically they're now made from sunflower, soy lecithin, and even cabbage!

Benefits and Effects

PS helps the entire body by keeping cellular membranes strong and healthy. Studies have shown PS to have substantial benefits for both body and brain.

Reducing the Negative Effects of Stress

PS reduces the release of cortisol “the stress hormone.” Cortisol provides the body with a boost of energy for emergency situations. This is done by converting a portion of the body’s protein stores into glucose. This fuels the “fight/flight” response.

High levels of cortisol levels over extended periods can lead to hypertension, suppressed libido, metabolic syndrome, hyperglycemia, among other physical problems.

PS can be used to significantly reduce cortisol levels in subjects in stressful situations. Helping to maintain the efficiency of the adrenal glands, especially when there is mental stress. Also it's been shown to improve mood and help regulate the heart rate under stress. Acting as an anxiolytic, which improves mood, reducing irritability, and results in a relaxed feeling.

Alleviates Depression

PS can substantially improve symptoms of depression in people of all ages. Studies of geriatric patients of both sexes who experienced depression late in life showed that PS improved their memory and reduced depression-related cognitive impairment. In otherwise healthy young males, PS reduced symptoms of distress and improved emotional responses. For children with depression, PS and omega-3 fatty acids improved attention and cognition and reduced symptoms of depression.

Improves Memory

Japanese research of adults aged 50+ who had memory problems showed that PS increased both verbal recall and overall memory performance.

Relieves Symptoms of Parkinson’s Disease and Alzheimer’s

When Alzheimer’s patients were tested they showed positive results. Significantly increasing verbal fluency, improving memory and lifting mood.

Research has conclusively shown that PS improves memory, increases learning the ability, and verbal fluidity, and reduces brain inflammation in Alzheimer’s patients.

It has also been cited as a valuable adjunct therapy for Parkinson’s Disease. Increasing the levels of dopamine available in the body, improving brain function and mood.

Delays the Onset of Age-Related Cognitive Decline

As we get older the body’s internal systems and metabolism become less efficient. This causes deficiencies which can lead to substantial memory loss and other cognitive impairment. Researchers believe that supplementation with PS and other nutrients can delay the onset of age-related cognition issues, although research is still ongoing.

How It Works

PS is primarily used by the body as a structural component of cellular membranes. PS appears to increase cell fluidity, facilitating the entrance of nutrients and the discharge of waste products. In order words, making the cells more efficient.

PS is also involved in transferring information from one nerve cell to another and is instrumental in initiating blood clotting and in triggering the elimination of dead cells. PS appears to upregulate specific enzymes and downregulate others. Decreasing the production and release of acetylcholinesterase, which breaks down the neurotransmitter acetylcholine. Lowering the levels of acetylcholine increases the amount of available acetylcholine. Which is closely associated with all aspects of cognition. Being able to boost acetylcholine levels is why PS is a breakthrough in Alzheimer’s disease treatment. One of the effects of Alzheimer’s is cholinergic hypofunction, which is due to acetylcholine deficiency and cognitive decline.

PS has also been shown to increase Nerve Growth Factor (NGF), which supports the creation, maintenance, and repair of brain cells. Making it a great way to build long-term lasting structural improvements to the brain.


The standard base dose for adults is 100mg taken three times daily. Start with the lowest effective dosage, then increase as required. If you are pregnant or breastfeeding you should consult your physicians before taking PS.

Side Effects

PS is very well tolerated when taken in doses of 300mg or less daily.

Reported side effects include insomnia and upset stomach, but when taken at higher dosages.

PS has been safely administered to adults for more than six months and to children for up to 4 months.


A common supplement to stack with Phosphatidylserine is other cognitive enhancing supplements, in order to maximize its effects.

A Natural Stack

Taken 1-2 times per day

Where to Buy

Phosphatidylserine supplements are readily available online. I recommend buying Phosphatidylserine online from, as they are a one-stop-shop for nootropic supplements.

Phosphatidylserine is an efficient multitasking nootropic, which keeps both body and brain working at optimal levels. Keeping your brain working better as you get older.

It increases the levels of brain chemicals responsible for enhancing motivation, mood, and cognition. It's also been shown to help reduce stress and fight depression.

If you want to maximize your physical and mental capabilities. Stay sharp as you get older, then Phosphatidylserine is worth checking out.

Have you used Phosphatidylserine before? What benefits did you experience?

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