CILTEP Review: Is It Worth The Hype?

There has been a lot of hype surrounding CILTEP since it blasted onto the market a few years back. With so many famous faces backing the product, from Dave Asprey of Bulletproof Coffee to the 4 Hour Work Week's Tim Ferris, I decided to do a CILTEP review to know if it was just that; hype.

As far as nootropics and brain enhancement supplements go, CILTEP's claim to fame is their ability to improve long term potentiation — converting short term memories into long term memories. In fact, the name is an acronym for Chemically Induced Long Term Potentiation.

In addition to improving your memory, this nootoropic supplement also boasts the ability to improve mental endurance, mood and alertness.

So how does this nootropic stack hold up? First, let's talk ingredients.

CILTEP Ingredients

CILTEP contains 3 key ingredients, Premium Artichoke extract, Forskolin and L-Phenylalanine.

Premium artichoke extract

Premium artichoke extract has long been used for its natural health benefits. As a nootropic, it  contains a powerful phytochemical called luteolin.

Luteolin is a PDE-4 inhibitor, meaning it prevents the enzyme responsible for breaking down cAMP (cyclic adenoside monophosphate) from doing so. This is important because cAMP allows neurotransmitters and hormones essential to memory formation to function properly. In short, this ingredient safe guards our ability to induce long term potentiation.


Forskolin is another key ingredient that has been included to increase levels of cAMP in neurons. cAMP is produced from ATP and forskolin activates the enzyme, adenylin cyclase, which is responsible for this production.

Combined with the artichoke extract and you now have enhanced learning and memory.


The final key ingredient in CILTEP is L-Phenylalanine. L-phenylalanine aids with the synthesis of dopamine, which is the hormone responsible for making you feel good.

As part of this nootropic stack, l-phenylalanine helps boost your concentration and motivation to achieve your desired goal. This makes it particularly effective for those using nootropics for studying.

While the aforementioned are the core ingredients, there are several others that play an integral role as well, including:

  • Acetyl L-Carnitine (ALCAR) — inhibits the enzyme that breaks down the neurotransmitter acetylcholine, which is essential for memory formation
  • Vitamin B6 — involved in the metabolism of amino acids that catalyze the synthesis of dopamine, essentially helping to increase mental focus and determination

In terms of being a memory enhancing nootropic, CILTEP is extraordinary thanks to its combination of artichoke and forskolin, especially. To really round it out, we think the addition of Huperzine A (another compound that inhibits the breakdown of acetylcholine) and/or Vinpocetine (protects against the effects of aging on your brain) would have truly made it the best nootropic for memory enhancement.

Does CILTEP Work?

This wouldn't be a real CILTEP review if we didn't discuss whether or not this nootropic blend actually works.

And by all accounts, CILTEP does work; however everyone's experiences are a little bit different because of your unique chemical composition.

The core ingredients in CILTEP are what make this product work so well when it comes to boosting your memory. As you can see above, the combination of PDE-4 inhibitors and cAMP increasing ingredients work to protect and replenish the neurotransmitters in your brain that are responsible for memory formation.

Benefits of Using CILTEP

Improved Memory

Perhaps the number one benefit of using CILTEP is how ti affects your long term potentiation. The unique combination of ingredients fuel the growth and production of vital neurotransmitters that aid in memory retention and recall.

This formula also protects the neuroplasticity of your brain, protecting it against the negative effects of aging; ie. memory loss or inability to understand and retain information even for a short period of time.

Obviously most people are using CILTEP because they want to boost their memory, but there are many other benefits to this nootropic stack.

Increased Alertness

CILTEP has been found to increase your wakefulness and alertness. In fact, many users like to stack CILTEP with small doses of stimulants. Caffeine is by far the most common and when taken with no more than 100-200 mg of caffeine, CILTEP gives you anywhere between 8-14 hours of laser focus to help you accomplish your daily tasks.

Laser Focus and Concentration

Improved focus and concentration are other benefits of using this memory enhancing nootropic as well. CILTEP uses a powerful form of Vitamin B6 known as Pyridoxal-5-Phosphate which is optimal for cognitive functioning. Unlike more generic forms of B6, P5P is metabolically active so it synthesizes neurotransmitters with greater ease.

Neurotransmitters like dopamine and serotonin are incredibly important for giving you feelings of self-motivation. So together with L-phenylalanine, B6 improves your mood and gives you maximum levels of motivation so you can achieve peek cognitive performance.


You're probably wondering, ‘does CILTEP have any side effects?' Is CILTEP safe to use? In general – and when taken as prescribed — CILTEP is safe to use.

Studies have found that increasing cAMP levels in moderation is safe because it reduces the amount of inflammation in cells.

That being said, it has been found that PDE-4 inhibitors cause nausea in some users. This typically happens only when taken in higher than recommended doses, but you may want to be aware of any sensitivities.

Some other potential side effects of CILTEP are drowsiness and increased mental fatigue the day following use. Depending on the individual, these side effects may be a result of a number of contributing factors such as general state of health before taking CILTEP, addition of other nootropics, or simply because they were mentally fatigued after powering through so many tasks in one day, thanks to the foucs-based benefits of the nootropic.

You may be interested to find that CILTEP is not FDA-approved. In the United States, dietary supplements are not required to get FDA-approval, however they are manufactured and packaged in an FDA-approved warehouse.


Natural Stacks, the creator of CILTEP, recommends taking 2-3 capsules in the morning on an empty stomach. They do not recommend taking more than 3 capsules within a 24 hour period either. They suggest taking 1-2 days off the nootropic each week, if you plan on using it regularly.

The CILTEP half life is approximately 12-14 hours, which is why they recommend taking it earlier in the day.

Smokers take note, Natural Stacks does not recommend using CILTEP if you are a smoker or using any products containing nicotine. They also include the use of other stimulants as they may exacerbate the effects and make the experience overwhelming and unpleasant.

CILTEP Studies

After stumbling across a study about forskolin-induced LTP published in the Journal of Neuropsychology in 2004, CILTEP creator Abelard Lindsay began researching the benefits and interactions of artichoke extract and forskolin.

His research led him to believe that together, the core ingredients of CILTEP could chemically induce long term memory formation, and give you deeper levels of concentration, making it optimal for studying.

You can find Lindsay's personal journey into long term potentiation on his forum here.

Where to Buy CILTEP

If you are wondering where to buy CILTEP, then stop wondering because there's only one place…online. North American residents can buy CILTEP online the easiest and have it delivered the fastest.

As far as I know, they also ship internationally to most countries. Just expect a longer wait time for it to arrive.

UPDATE: For anyone living in Australia or New Zealand you must place your order through their New Zealand warehouse.

The good news is, when you place an order through that link above, it is subject to their 100% money back guarantee. This means you have 30 days from the date of purchase to return any unopened bottles of product.

Final Thoughts

So after diving into CILTEP, I think it's safe to say that it does live up to much of the hype. CEOs, students, athletes and gamers alike, love using this product and benefit from either its memory enhancing nootropic effects or its ability to maximize your concentration.

Whether you're looking for a nootropics stack for studying, a powerful anti aging supplement for your mind or a tool for improving your social ability and mood, CILTEP can benefit you.

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