Adrafinil: The Ultimate Guide

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Adrafinil is a common nootropic used to increase your level of alertness and wakefulness. Though it possesses stimulant qualities, it does not create hyperactivity in the body, rather it fends off sleepiness.

There is much that is unknown about Adrafinil still, but below you will find a detailed report of what we do know, and how you can benefit from it.

Quick Facts

Adrafinil is also known as Olmifon or CRL-40028.

It is most often confused with Modafinil, though they are not the same. Adrafinil is however, a prodrug for Modafinil, which means if you take Adrafinil it will be metabolized in the liver and cause higher concentrations of Modafinil in your body.

Nootropics similar to Adrafinil include Verapamil, Butorphanol, Ketorolac Ophthalmic and Nystatin.

Adrafinil is banned by the World Anti Doping Agency (WADA) as it has been classified as a non specific stimulant (1).

Adrafinil Dosage

Standard dosage

The recommended dosage varies between 600-1200 mg daily, taken orally. As with all nootropics and supplements, it is always best to start with the lowest possible dose to see how your body reacts.

When To Take Adrafinil

Due to the fact that Adrafinil increases alertness, the best time to take Adrafinil is the morning on an empty stomach.

Some users prefer to split their dosage and take half upon waking and another half before lunch time. It is not recommended to take adrafinil in the afternoon or evening as it will impair your ability to sleep.

How Long Does Adrafinil Take To Work?

Most users begin to feel the effects of adrafinil 60-90 minutes after ingesting it, as it needs this time to become absorbed in your system and metabolized by the liver.

The typical peak time for performance is between hours 2-4 after ingestion, meaning you will likely feel your most alert and focused 2-4 hours after taking it. In this case, if you are planning on using adrafinil for studying or in-class focus, you will want to take it 1-2 hours prior.

How Long Does Adrafinil Last?

Studies show that the Adrafinil half-life is 1 hour in humans, however this is fairly misleading. Adrafinil is metabolized in the liver and is converted into modafinil, and the half life of modafinil is 15 hours. Simply put, you could feel the therapeutic effects of adrafinil all day long just from one dose.

Cycling Adrafinil

As with many nootropics, they should not be taken for uninterrupted extended periods of time. Instead, you should consider cycling it.

In addition to preventing negative side effects, cycling also reduces the odds of your body becoming immune to its effects.

An example of cycling would be to use it for 3 times per week for two weeks, followed by one week off. After your one week off, take it 3 times per week for one week, followed by two weeks off and repeat.
Adrafinil should not be taken for longer than 5 months in a row.

The Science Behind Adrafinil

What Is Adrafinil?

Adrafinil is a synthetic substance not found in the body or nature. It is a compound comprised of diphenylmethyl sulfinyl-2 acetohydroxamic acid, which is commonly used to promote wakefulness and improved alertness, making it a eugregoric agent.

It is most commonly known by its brand name Olmifon.

How Does Adrafinil Work?

As we mentioned above, there is much to be learned about Adrafinil and it is not fully understood how it works. That being said, adrafinil appears to mimic the chemical response that causes our body to go into “fight or flight” mode by increasing your body’s production of hypocretin.

Hypocretin is a neurotransmitter responsible for making you feel awake and alert. In fact, narcolepsy (condition that causes you to fall asleep easily) is caused by a lack of hypocretin in the brain.

As adrafinil increases your levels of hypocretin, it also leads your body to produce other hormones and neurotransmitters that affect your mental and physical energy levels, such as dopamine, norepinephrine and histamine.

Adrafinil also works to modulate Glutamate receptors, which is one of the reasons people use this nootropic for improving their cognitive functionality.

Glutamate is essential for improving memory, creating better neuronal communication and enhanced cognitive performance, and adrafinil works by inhibiting the breakdown of this important amino acid.

How Is Adrafinil Metabolized & Eliminated?

Adrafinil — when taken orally, as prescribed — is metabolized in the liver where it turns into modafinilic acid or modafinil sulfone. These metabolites form a modified version of modafinil.

Adrafinil is eliminated through plasma and urine, though it appears to go faster through plasma. As it is found in both places, it is easy to detect. It also happens to be a banned substance by the WADA, so if you are an athlete who undergoes regular drug testing, you should not use Adrafinil.

Is Adrafinil Safe To Use?

While there are not too many negative side effects, there are some notable Adrafinil side effects that you may want to take into consideration before using it.

Some users have experienced headaches, dizziness or stomach issues like nausea or discomfort.

With long term use, you may be putting your liver in danger. Adrafinil causes a buildup of enzymes in your liver and when used in higher dosages for long periods of time, you risk reducing the function of your liver.

Who Uses Adrafinil?

Adrafinil is a common nootropic used by students who are looking for a burst in energy to stay on top of their studies, especially during exam periods. As its primary function is to increase wakefulness, it could be beneficial for individuals on shift work or working nights.
This nootropic is not recommended for athletes as it is banned by WADA.

Clinical Studies On Adrafinil

There have not been too many studies on the effects of adrafinil as a nootropic, however there have been some clinical research into its effects on orofacial dyskinesia (involuntary movements of the face and mouth, sometimes found in patients with Parkinson’s Disease).

One study found (2) that by using 900 mg of Adrafinil each day for a period of 10 months led to orofacial dyskinesia. It was also found that even after a 4 month withdrawal period, subjects were still experiencing abnormal facial movements.

Where To Buy Adrafinil

Firstly I don't want you to fall into this trap… there is speculation that Cerebral Health is selling fake Adrafinil powder, as noted on Reddit.

Several people claim that not only did their adrafinil look and smell different (which is weird), but they literally experienced no any effects after taking it for an extended period of time.

I personally get mine here from and have only experienced quality effects.

Common Stacks Used with Adrafinil

Noopept And Adrafinil Stack

If you are looking for enhanced focus, memory and wakefulness, then this stack is for you. When used together appropriately, noopept and adrafinil compliment each other nicely.

To use this stack, take 10-30 mg of Noopept 3 times daily. Take 150 mg of Adrafinil first thing in the morning with your first dose of Noopept.
Whatever you do, do not take any additional adrafinil or you will impair your sleeping.

Adrafinil And Caffeine Stack

Caffeine is a well known stimulant and one that is most commonly used, but a lot of us drink so many cups of joe that we build up a tolerance. By mixing caffeine and adrafinil you can experience similar or better results.

To stack together, take 200-300 mg of Adrafinil first thing in the morning and either have a cup of coffee or 200 mg of caffeine supplement.

You might think using them together is redundant, but their purposes and effects are slightly different. Adrafinil works to create wakefulness, while caffeine (an adenosine competitive inhibitor) works to prevent sleepiness.

Note — be sure to drink plenty of water or you may experience severe headaches, dizzy spells or diarrhea.

The Ultimate Adrafinil Stack for Studying

Adrafinil is very effective on its own, but can be stacked with several other nootropics to create the ultimate nootropic stack for studying.*

If you need to pull an all nighter during exam time or before a big project is due, then try mixing the following nootropics together:

  • Adrafinil — for wakefulness (use approximately 150 mg**)
  • Caffeine — to reduce sleepiness (use approximately 150 mg**)
  • Pramiracetam — for improved choline uptake and enhanced memory recall (use approximately 100 mg**)
  • L-Theanine — to reduce stress and anxiety for a relaxed study session (use approximately 50 mg**)

*This is not recommended for new nootropic users.

** Recommend using lower dosages and tweaking over time as you find what works best for you and your body

Adrafinil may not be for everyone. As we mentioned, it is a derivative of Modafinil which has been found to be a much more reliable and tested nootropic. That being said, when used properly or stacked with other cognitive and energy enhancing nootropics, the benefits of adrafinil are plentiful.

Depending on your needs and desired outcomes, you may experience periods of great focus and alertness, but you may also experience negative side effects such as headaches or dizziness. As with any nootropic, start with the lowest recommended dosage and see how your body reacts.


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